This guide is a practical resource for communities seeking to assess and enhance their readiness for entrepreneur-led economic development. Drawing on the field experiences of NetWork Kansas and eCommunities, the guide outlines why readiness matters and introduces a developmental framework rooted in four foundations: entrepreneurial talent, resources, leadership and community capacity. It offers several tools, including the Community Life Cycle Matrix and three readiness assessment tests. These help communities evaluate commitment levels, resources and strategic alignment before launching entrepreneurial initiatives. The guide emphasises the role of local leadership, cross-sectoral collaboration and long-term commitment as key success factors. It is particularly relevant for rural or smaller communities aiming to build inclusive, sustainable and homegrown economic development ecosystems.